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[문헌]CHIRALPAK ZWIX/Amino acid/Small peptide
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CHIRALPAK ZWIX 컬럼을 이용하여 아미노산, di-,tripeptide 분석을 한 포스터 발표 자료입니다.
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Introduction
Synthetic peptides occupy an important position in therapeutics and drug discovery. They represent the effective
and innovative solutions for new and/or unmet medical requirements.
In concert with the peptide synthesis and their applications, appropriate analytical methods are needed for assays of the
chiral amino acid and small peptide building blocks, for monitoring and controlling the stereochemistry of the
synthetic process, for assessing the structural integrity (amino acid composition, sequence and chirality) of the final
peptides, as well as for determining the constituents of the amples back from biological media. HPLC, often combined
to MS detection, has been the most frequently used technique for these purposes. However, developing efficient
and reliable methods involving the molecular chirality information for control and characterization of synthetic
peptides remains challenging.
In response to such challenges, the newly developed zwitterionic chiral stationary phases, namely CHIRALPAK®
ZWIX(+) and CHIRALPAK® ZWIX(-), have been explored in HPLC for direct stereo-selective resolution of amino acids and
oligopeptides (di- and tripeptides mainly) using LC-MS compatible mobile phase conditions.
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