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[Ref.]Chiral Drug Separation
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Encyclopedia of Chemical Processing DOI: 10.1081/E-ECHP-120039232
Chiral Drug Separation
Bingyun Li
Donald T. Haynie
Biomedical Engineering and Physics, Bionanosystems Engineering Laboratory, Center for
Applied Physics Studies, Louisiana Tech University, Ruston, Louisiana, U.S.A.
INTRODUCTION
Consideration of chirality is now an integral part of drug research and development and the regulatory
process. There is no choice! Enantiomeric forms of a drug can differ in potency, toxicity, and behavior in
biological systems. Enantiomers of all chiral bioactive molecules have to be separated and tested. The Food
and Drug Administration (FDA, U.S.A.), and regulatory authorities in Europe, China, and Japan have
provided guidelines indicating that preferably only the active enantiomer of a chiral drug should be brought
to market. This entry discusses the main chiral drug separation methods, viz. gas chromatography (GC), highperformance
liquid chromatography (HPLC), capillary electrophoresis (CE), and some new techniques. The
first part presents the concept of molecular chirality and some examples of chiral drugs. The importance
of chiral drug separation is briefly discussed. The second part describes the main chiral drug separation
techniques and related chiral recognition mechanisms, as well as available chiral selectors. Some typical
examples are given, and the pros and cons of chromatographic and capillary electrophoretic techniques are
compared. Readers are also referred to specialized review articles for details. The last part summarizes
and briefly discusses future development trends in drug separation techniques.
- chiraldrugseparation.pdf (183.5KB) (1)
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